Role of B cells in TH cell responses in a mouse model of asthma
TP Wypych, R Marzi, GF Wu, A Lanzavecchia… - Journal of Allergy and …, 2018 - Elsevier
Background The importance of B lymphocytes to present antigens for antibody production is
well documented. In contrast, very little is known about their capacity to influence CD4+ T-
cell activation during a primary or secondary response to allergens. Objective Using mouse
models of asthma, we investigated the role of B cells as antigen-presenting cells in priming
and maintenance of TH cell responses. Methods Mice were immunized through the
intranasal route with house dust mite (HDM) extract derived from Dermatophagoides …
well documented. In contrast, very little is known about their capacity to influence CD4+ T-
cell activation during a primary or secondary response to allergens. Objective Using mouse
models of asthma, we investigated the role of B cells as antigen-presenting cells in priming
and maintenance of TH cell responses. Methods Mice were immunized through the
intranasal route with house dust mite (HDM) extract derived from Dermatophagoides …
